General Information

  • ID:  hor006544
  • Uniprot ID:  P45653
  • Protein name:  Progonadoliberin-3
  • Gene name:  gnrh3
  • Organism:  Salmo trutta (Brown trout)
  • Family:  GnRH family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Salmo (genus), Salmoninae (subfamily), Salmonidae (family), Salmoniformes (order), Protacanthopterygii, Euteleosteomorpha (cohort), Clupeocephala, Osteoglossocephalai, Teleostei (infraclass), Neopterygii (subclass), Actinopteri (class), Actinopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0007165 signal transduction
  • GO CC:  GO:0005576 extracellular region; GO:0005615 extracellular space

Sequence Information

  • Sequence:  QHWSYGWLPGGKRSVGELEATIKMMDTGGVVALPEETSAHFSERLRPYDVILKKWMPHK
  • Length:  59
  • Propeptide:  MDLSNRTVVQVVVLALVAQVTLSQHWSYGWLPGGKRSVGELEATIKMMDTGGVVALPEETSAHFSERLRPYDVILKKWMPHK
  • Signal peptide:  MDLSNRTVVQVVVLALVAQVTLS
  • Modification:  T1 Pyrrolidone carboxylic acid;T10 Glycine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Stimulates the secretion of gonadotropins.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-P45653-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor006544_AF2.pdbhor006544_ESM.pdb

Physical Information

Mass: 778750 Formula: C306H471N83O84S3
Absent amino acids: CN Common amino acids: GEKL
pI: 9.07 Basic residues: 11
Polar residues: 15 Hydrophobic residues: 18
Hydrophobicity: -53.05 Boman Index: -8642
Half-Life: 0.8 hour Half-Life Yeast: 10 min
Half-Life E.Coli: >10 hour Aliphatic Index 71.02
Instability Index: 6760.85 Extinction Coefficient cystines: 19480
Absorbance 280nm: 335.86

Literature

  • PubMed ID:  1587389
  • Title:  The Atlantic salmon prepro-gonadotropin releasing hormone gene and mRNA.